Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failure.

ABSTRACT: Chronic hypertension is a key risk factor for heart failure. However, the underlying molecular mechanisms are not fully understood. Our previous studies found that the valosin-containing protein (VCP), an ATPase-associated protein, was significantly decreased in the hypertensive heart tissues. In this study, we tested the hypothesis that restoration of VCP protected the heart against pressure overload-induced heart failure. With a cardiac-specific transgenic (TG) mouse model, we showed that a moderate increase of VCP was able to attenuate chronic pressure overload-induced maladaptive cardiac hypertrophy and dysfunction. RNA sequencing and a comprehensive bioinformatic analysis further demonstrated that overexpression of VCP in the heart normalized the pressure overload-stimulated hypertrop

SUBMITTER: Zhou N 

PROVIDER: S-EPMC7426568 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature