Effect of D-Cycloserine on the Effect of Concentrated Exposure and Response Prevention in Difficult-to-Treat Obsessive-Compulsive Disorder: A Randomized Clinical Trial.

ABSTRACT:

Importance

Evidence is lacking for viable treatment options for patients with difficult-to-treat obsessive-compulsive disorder (OCD). It has been suggested that D-cycloserine (DCS) could potentiate the effect of exposure and response prevention (ERP) treatment, but the hypothesis has not been tested among patients with difficult-to-treat OCD.

Objective

To evaluate whether DCS potentiates the effect of concentrated ERP among patients with difficult-to-treat OCD.

Design, setting, and participants

The study was a randomized placebo-controlled triple-masked study with a 12-month follow-up. Participants were adult outpatients with difficult-to-treat OCD. A total of 220 potential participants were referred, of whom 36 did not meet inclusion criteria and 21 declined to parti

SUBMITTER: Kvale G 

PROVIDER: S-EPMC7426745 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature