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Disparity in outcomes of melanoma adjuvant immunotherapy by demographic profile.


ABSTRACT: Background:Randomized comparisons have demonstrated survival benefit of adjuvant immunotherapy in node-positive melanoma patients but have limited power to determine if this benefit persists across various demographic factors. Materials & methods:We assessed the impact of demographic factors on the survival benefit of adjuvant immunotherapy in a database of 38,189 node-positive melanoma patients using the Kaplan-Meier method and Cox proportional hazards models. Results:All assessed demographic factors other than race significantly impacted survival of node-positive melanoma patients in univariate analysis. In multivariable analysis, only the age group interacted with immunotherapy. Conclusion:Analysis of this large database of unselected node-positive melanoma patients demonstrated a positive survival benefit of immunotherapy across all demographic factors assessed and the impact was greater for patients 65 years of age and older.

SUBMITTER: Ikeguchi A 

PROVIDER: S-EPMC7426750 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Disparity in outcomes of melanoma adjuvant immunotherapy by demographic profile.

Ikeguchi Alexandra A   Machiorlatti Michael M   Vesely Sara K SK  

Melanoma management 20200716 2


<h4>Background</h4>Randomized comparisons have demonstrated survival benefit of adjuvant immunotherapy in node-positive melanoma patients but have limited power to determine if this benefit persists across various demographic factors.<h4>Materials & methods</h4>We assessed the impact of demographic factors on the survival benefit of adjuvant immunotherapy in a database of 38,189 node-positive melanoma patients using the Kaplan-Meier method and Cox proportional hazards models.<h4>Results</h4>All  ...[more]

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