Disparity in outcomes of melanoma adjuvant immunotherapy by demographic profile.

ABSTRACT:

Background

Randomized comparisons have demonstrated survival benefit of adjuvant immunotherapy in node-positive melanoma patients but have limited power to determine if this benefit persists across various demographic factors.

Materials & methods

We assessed the impact of demographic factors on the survival benefit of adjuvant immunotherapy in a database of 38,189 node-positive melanoma patients using the Kaplan-Meier method and Cox proportional hazards models.

Results

All assessed demographic factors other than race significantly impacted survival of node-positive melanoma patients in univariate analysis. In multivariable analysis, only the age group interacted with immunotherapy.

Conclusion

Analysis of this large database of unselected node-positive melanoma

SUBMITTER: Ikeguchi A 

PROVIDER: S-EPMC7426750 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature