Different functions of two putative Drosophila α₂δ subunits in the same identified motoneurons.

ABSTRACT: Voltage gated calcium channels (VGCCs) regulate neuronal excitability and translate activity into calcium dependent signaling. The α₁ subunit of high voltage activated (HVA) VGCCs associates with α₂δ accessory subunits, which may affect calcium channel biophysical properties, cell surface expression, localization and transport and are thus important players in calcium-dependent signaling. In vertebrates, the functions of the different combinations of the four α₂δ and the seven HVA α₁ subunits are incompletely understood, in particular with respect to partially redundant or separate functions in neurons. This study capitalizes on the relatively simpler situation in the Drosophila genetic model containing two neuronal putative α₂δ subuni

SUBMITTER: Heinrich L 

PROVIDER: S-EPMC7426832 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature