Broadband slow-wave modulation in posterior and anterior cortex tracks distinct states of propofol-induced unconsciousness.

ABSTRACT: A controversy has developed in recent years over the roles of frontal and posterior cortices in mediating consciousness and unconsciousness. Disruption of posterior cortex during sleep appears to suppress the contents of dreaming, yet activation of frontal cortex appears necessary for perception and can reverse unconsciousness under anesthesia. We used anesthesia to study how regional cortical disruption, mediated by slow wave modulation of broadband activity, changes during unconsciousness in humans. We found that broadband slow-wave modulation enveloped posterior cortex when subjects initially became unconscious, but later encompassed both frontal and posterior cortex when subjects were more deeply anesthetized and likely unarousable. Our results suggest that unconsciousness under anesth

SUBMITTER: Stephen EP 

PROVIDER: S-EPMC7426927 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature