Association between the interferon-γ +874T/A polymorphism and susceptibility to hepatitis B virus infection: a meta-analysis.

ABSTRACT:

Objective

This study investigated the correlation between the interferon (IFN)-γ +874T/A polymorphism and hepatitis B virus (HBV) susceptibility using meta-analysis.

Methods

PubMed, EMBASE, Web of Science, CNKI, and China Wanfang databases were searched for case-control studies investigating the IFN-γ +874T/A polymorphism and HBV susceptibility from the time of database establishment to April 2020. Stata 15.0 software was used, and the subgroups of ethnicity and Hardy-Weinberg equilibrium were analyzed.

Results

Thirteen articles were included in this study. Significant differences were seen in the allelic model, dominant model, homozygous model, and heterozygous model, but heterogeneity was high. Analysis of the East Asian population revealed combined odds ratios of t

SUBMITTER: Li L 

PROVIDER: S-EPMC7427031 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature