Nicotinamide riboside with pterostilbene (NRPT) increases NAD⁺ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI.

ABSTRACT:

Background

Preclinical studies have identified both NAD⁺ and sirtuin augmentation as potential strategies for the prevention and treatment of AKI. Nicotinamide riboside (NR) is a NAD⁺ precursor vitamin and pterostilbene (PT) is potent sirtuin activator found in blueberries. Here, we tested the effect of combined NR and PT (NRPT) on whole blood NAD⁺ levels and safety parameters in patients with AKI.

Methods

We conducted a randomized, double-blind, placebo-controlled study of escalating doses of NRPT in 24 hospitalized patients with AKI. The study was comprised of four Steps during which NRPT (5 subjects) or placebo (1 subject) was given twice a day for 2 days. NRPT dosing was increased in each Step: Step 1250/50 mg, Step 2500/100 mg, Step 3750

SUBMITTER: Simic P 

PROVIDER: S-EPMC7427083 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature