Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice.

ABSTRACT: Leptin plays a role in central nervous system developmental programs and intercurrent physiological processes related to body fat regulation. The timing and neuromolecular mechanisms for these effects are relevant to the prevention and treatment of obesity. Factors implicated in a body weight "set point" including dietary fat, circulating leptin, and other adipokines tend to covary with adiposity and are difficult to disarticulate experimentally. To dissociate leptin effects from adiposity and diet, we created a transgenic mouse in which leptin expression is regulated by doxycycline exposure. Using this system, we investigated the physiological consequences of developmentally-timed transient hyperleptinemia on subsequent adiposity. We evaluated physiological effects of leptin elevation dur

SUBMITTER: Skowronski AA 

PROVIDER: S-EPMC7427106 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature