Ontology highlight
ABSTRACT:
SUBMITTER: Jackson Z
PROVIDER: S-EPMC7427107 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in immunology 20200807
Chimeric antigen receptor T cells (CAR-T cell) targeting CD19 are effective against several subtypes of CD19-expressing hematologic malignancies. Centralized manufacturing has allowed rapid expansion of this cellular therapy, but it may be associated with treatment delays due to the required logistics. We hypothesized that point of care manufacturing of CAR-T cells on the automated CliniMACS Prodigy<sup>®</sup> device allows reproducible and fast delivery of cells for the treatment of patients w ...[more]