Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine.

ABSTRACT:

Background/objective

Type-I interferons contribute to pathogenesis in systemic lupus erythematosus, including nephritis. Interferons consist of a family of 16 proteins yet are often characterized in patients without knowledge of the specific interferon subtypes involved. Different interferons may function in the kidneys, and other organs, relative to what is often measured in patient blood. Moreover, antibodies to interferons may potentially modulate systemic or organ-specific interferon activity. The aim of this study was to characterize global interferon activity levels and identify autoantibodies to the 12 interferon α subtypes in patient serum and urine.

Methods

Interferon activity levels in serum and urine were measured using an interferon bioassay. Anti-interferon and

SUBMITTER: Harris BD 

PROVIDER: S-EPMC7427124 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature