Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening.

ABSTRACT: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emphasized the urgency to develop effective therapeutics. Drug repurposing screening is regarded as one of the most practical and rapid approaches for the discovery of such therapeutics. The 3C like protease (3CL ^pro ), or main protease (M ^pro ) of SARS-CoV-2 is a valid drug target as it is a specific viral enzyme and plays an essential role in viral replication. We performed a quantitative high throughput screening (qHTS) of 10,755 compounds consisting of approved and investigational drugs, and bioactive compounds using a SARS-CoV-2 3CL ^pro assay. Twenty-three small molecule inhibitors of SARS-CoV-2 3CL ^pro have been ide

SUBMITTER: Zhu W 

PROVIDER: S-EPMC7427131 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature