Perinatal and postnatal exposures and risk of young-onset breast cancer.

ABSTRACT:

Background

Perinatal factors have been associated with some adult health outcomes, but have not been well studied in young-onset breast cancer. We aimed to evaluate the association between young-onset breast cancer and perinatal exposures and to explore etiologic heterogeneity in the relationship between associated perinatal factors and estrogen receptor status of the tumor.

Methods

We addressed this in a sister-matched case-control study. Cases were women who had been diagnosed with ductal carcinoma in situ or invasive breast cancer before the age of 50. Each case had a sister control who was free of breast cancer up to the same age at which her case sister developed the disease. The factors considered were self-reported and included the mother's preeclampsia in that pregna

SUBMITTER: Diaz-Santana MV 

PROVIDER: S-EPMC7427289 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature