Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.

ABSTRACT: Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the NHLBI. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have yielded improvements in supportive care, which have translated into improved patient outcomes. Novel therapeutics have largely failed to translate from promising preclinical findings into improved patient outcomes in late-phase clinical trials. Recent advances in personalized medicine, "big data," causal inference using observational data, novel clinical trial designs, preclinical disease modeling, and understanding of recovery from acute illness promise to transform the methods of pulmonary and critical care c

SUBMITTER: Semler MW 

PROVIDER: S-EPMC7427373 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature