Single-Session Bronchial Thermoplasty Guided by ¹²⁹Xe Magnetic Resonance Imaging. A Pilot Randomized Controlled Clinical Trial.

ABSTRACT: Rationale: Adverse events have limited the use of bronchial thermoplasty (BT) in severe asthma.Objectives: We sought to evaluate the effectiveness and safety of using ¹²⁹Xe magnetic resonance imaging (¹²⁹Xe MRI) to prioritize the most involved airways for guided BT.Methods: Thirty subjects with severe asthma were imaged with volumetric computed tomography and ¹²⁹Xe MRI to quantitate segmental ventilation defects. Subjects were randomized to treatment of the six most involved airways in the first session (guided group) or a standard three-session BT (unguided). The primary outcome was the change in Asthma Quality of Life Questionnaire score from baseline to 12 weeks after the first BT for the guided group compared with after three treatm

SUBMITTER: Hall CS 

PROVIDER: S-EPMC7427382 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature