Antibacterial activity and mechanism of sanguinarine against Providencia rettgeri in vitro.

ABSTRACT:

Background

Sanguinarine (SAG), a benzophenanthridine alkaloid, occurs in Papaveraceas, Berberidaceae and Ranunculaceae families. Studies have found that SAG has antioxidant, anti-inflammatory, and antiproliferative activities in several malignancies and that it exhibits robust antibacterial activities. However, information reported on the action of SAG against Providencia rettgeri is limited in the literature. Therefore, the present study aimed to evaluate the antimicrobial and antibiofilm activities of SAG against P. rettgeri in vitro.

Methods

The agar dilution method was used to determine the minimum inhibitory concentration (MIC) of SAG against P. rettgeri. The intracellular ATP concentration, intracellular pH (pH_in), a

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7427548 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature