Real-time measurement of diffusion exchange rate in biological tissue.

ABSTRACT: Diffusion exchange spectroscopy (DEXSY) provides a means to isolate the signal attenuation associated with exchange from other sources of signal loss. With the total diffusion weighting b₁+b₂=b_s held constant, DEXSY signals acquired with b₁=0 or b₂=0 have no exchange weighting, while a DEXSY signal acquired with b₁=b₂ has maximal exchange weighting. The exchange rate can be estimated by fitting a diffusion exchange model to signals acquired with variable mixing times. Conventionally, acquired signals are normalized by a signal with b₁=0 and b₂=0 to remove the decay due to spin-lattice relaxation. Instead, division by a signal with equal b_s but b₁=0 or b₂=0 red

SUBMITTER: Williamson NH 

PROVIDER: S-EPMC7427561 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature