Target Analysis and Mechanism of Podophyllotoxin in the Treatment of Triple-Negative Breast Cancer.

ABSTRACT:

Background

As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored.

Methods

We used cell proliferation assay, scratch and transwell experiments, and cell cycle and apoptosis analyses to observe the intervention effect of podophyllotoxin on breast cancer. Furthermore, we analyzed the differences between GSE31448, GSE65194, and GSE45827 in the Gene Expression Omnibus database (GEO) and explored the differential genes using a STRING database. Centiscape2.2, MCODE cluster analysis and KEGG pathway analysis were used to identify the most significant gene differences. Next, we utilized BATMAN-TCM and TCMSP databases for furt

SUBMITTER: Zhang W 

PROVIDER: S-EPMC7427588 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature