Reliability of dopamine transporter PET measurements with [¹⁸F]FE-PE2I in patients with Parkinson's disease.

ABSTRACT:

Background

Reliable quantification of dopamine transporter (DAT), a biomarker for Parkinson's disease (PD), is essential for diagnostic purposes as well as for evaluation of potential disease-modifying treatment. Due to degeneration of dopaminergic neurons and thus lower expected radioligand binding to DAT, higher measurement variability in PD patients might be expected than earlier reproducibility results in healthy controls. Therefore, we aimed to examine the test-retest properties of [¹⁸F]FE-PE2I-PET in PD patients.

Methods

Nine patients with PD (Hoehn and Yahr stage < 3) were included (men/women 6/3; mean age 65.2 ± 6.8 years). Each patient underwent two [¹⁸F]FE-PE2I-PET measurements within 7-28 days. The outcome measure was non-displaceable binding

SUBMITTER: Kerstens VS 

PROVIDER: S-EPMC7427674 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature