Molecular characteristics of the VP1 region of enterovirus 71 strains in China.

ABSTRACT:

Background

Enterovirus 71 (EV71) is the most commonly implicated causative agent of severe outbreaks of paediatric hand, foot, and mouth disease (HFMD).VP1 protein, a capsid protein of EV71, is responsible for the genotype of the virus and is essential for vaccine development and effectiveness. However, the genotypes of EV71 isolates in China are still not completely clear.

Methods

The VP1 gene sequences of 3712 EV71 virus strains from China, excluding repetitive sequences and 30 known EV71 genotypes as reference strains, between 1986 and 2019 were obtained from GenBank. Phylogenetic tree, amino acid homology, genetic variation and genotype analyses of the EV71VP1 protein were performed with MEGA 6.0 software.

Results

The amino acid identity was found to be 88.33%-100

SUBMITTER: Sun H 

PROVIDER: S-EPMC7427758 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature