Versatile formation of supported lipid bilayers from bicellar mixtures of phospholipids and capric acid.

ABSTRACT: Originally developed for the structural biology field, lipid bicelle nanostructures composed of long- and short-chain phospholipid molecules have emerged as a useful interfacial science tool to fabricate two-dimensional supported lipid bilayers (SLBs) on hydrophilic surfaces due to ease of sample preparation, scalability, and versatility. To improve SLB fabrication prospects, there has been recent interest in replacing the synthetic, short-chain phospholipid component of bicellar mixtures with naturally abundant fatty acids and monoglycerides, i.e., lauric acid and monocaprin. Such options have proven successful under specific conditions, however, there is room for devising more versatile fabrication options, especially in terms of overcoming lipid concentration-dependent SLB formation lim

SUBMITTER: Sut TN 

PROVIDER: S-EPMC7427796 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature