An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.

ABSTRACT: Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that is induced in ILC3s during intestinal inflammation. Deletion of circKcnt2 causes gut ILC3 activation and severe colitis in mice. Mechanistically, circKcnt2, as a nuclear circRNA, recruits the nucleosome remodeling deacetylase (NuRD) complex onto Batf promoter to inhibit Batf expression; this in turn suppresses Il17 expression and thereby ILC3 inactivation to promote innate colitis resolution. Furthermore, Mbd3^-/-Rag1^-/- and circKcnt2^-/-Rag1^-/- mice develop severe innate colitis following dextran sodium s

SUBMITTER: Liu B 

PROVIDER: S-EPMC7427797 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature