Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway.

ABSTRACT:

Objectives

The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and the underlying mechanism.

Methods

Information about the chemical compositions of GD was obtained from extensive literature reports. Potential target genes were predicted using PharmMapper and analyzed using Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). To validate the results from bioinformatics analyses, an aqueous extract of GD was administered to type 2 diabetic rats established by feeding a high-fat and high-sugar diet followed by STZ injection. Key proteins of the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway were investigated by immunoblotting.

Results

The blood glucose of the rats in the GD treatment group was significa

SUBMITTER: Xu W 

PROVIDER: S-EPMC7427804 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature