New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP.

ABSTRACT: Mouse models are essential to study and comprehend normal and malignant hematopoiesis. The ideal preclinical model should mimic closely the human malignancy. This means that these mice should recapitulate the clinical behavior of the human diseases such as cancer and therapeutic responses with high reproducibility. In addition, the genetic mutational status, the cell phenotype, the microenvironment of the tumor and the time until tumor development occurs, should be mimicked in a preclinical model. This has been particularly challenging for human angioimmunoblastic lymphoma (AITL), one of the most prominent forms of peripheral T-cell lymphomas. A complex network of interactions between AITL tumor cells and the various cells of the tumor microenvironment has impeded the study of AITL pathoge

SUBMITTER: Mhaidly R 

PROVIDER: S-EPMC7427806 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature