Predictive factors of rapid linear renal progression and mortality in patients with chronic kidney disease.

ABSTRACT:

Background

Risk factors predictive of rapid linear chronic kidney disease (CKD) progression and its associations with end-stage renal disease (ESRD) and mortality requires further exploration, particularly as patients with linear estimated glomerular filtration rate (eGFR) trajectory represent a clear paradigm for understanding true CKD progression.

Methods

A linear regression slope was applied to all outpatient eGFR values for patients in the Salford Kidney Study who had ≥2 years follow-up, ≥4 eGFR values and baseline CKD stages 3a-4. An eGFR slope (ΔeGFR) of ≤ - 4 ml/min/1.73m²/yr defined rapid progressors, whereas - 0.5 to + 0.5 ml/min/1.73m²/yr defined stable patients. Binary logistic regression was utilised to explore variables associated with rapi

SUBMITTER: Ali I 

PROVIDER: S-EPMC7427893 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature