HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway.

ABSTRACT:

Background

Endothelial injury is one of the predominant pathophysiological characteristics of sepsis and is the major cause of sepsis-induced multiple organ failure. Endothelial pyroptosis is a fatal mechanism of endothelial injury in sepsis, and specific, effective therapies are lacking. Although hepatocyte growth factor (HGF) has been shown to have anti-apoptotic and anti-necrotic effects, whether it prevents pyroptosis to improve endothelial injury in sepsis remains unclear.

Methods

Recombinant HGF was intravenously injected into mice with sepsis caused by caecal ligation puncture (CLP). Histopathological examination and transmission electron microscopy (TEM) were used to measure lung vascular endothelial injury. Lipopolysaccharide (LPS) was transfected into EA.hy926 cell

SUBMITTER: Peng F 

PROVIDER: S-EPMC7427898 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature