Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence.

ABSTRACT:

Objective

Youth with a family history of alcohol use disorder (family history positive [FHP]) are at increased risk for developing maladaptive substance use relative to family history negative (FHN) peers. Building on earlier studies demonstrating morphological differences and distinct patterns of neural activation in FHP, the purpose of the present study was to investigate differential intrinsic functional connectivity among brain networks indexing premorbid risk of developing alcohol use disorder (AUD).

Method

The current study examined intrinsic functional connectivity using resting state functional magnetic resonance imaging in 191 adolescents 13 to 18 years of age with and without family history of AUD via independent component analysis, a method enabling data-driven in

SUBMITTER: Vaidya JG 

PROVIDER: S-EPMC7428193 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature