Disynaptic cerebrocerebellar pathways originating from multiple functionally distinct cortical areas.

ABSTRACT: The cerebral cortex and cerebellum both play important roles in sensorimotor processing, however, precise connections between these major brain structures remain elusive. Using anterograde mono-trans-synaptic tracing, we elucidate cerebrocerebellar pathways originating from primary motor, sensory, and association cortex. We confirm a highly organized topography of corticopontine projections in mice; however, we found no corticopontine projections originating from primary auditory cortex and detail several potential extra-pontine cerebrocerebellar pathways. The cerebellar hemispheres were the major target of resulting disynaptic mossy fiber terminals, but we also found at least sparse cerebrocerebellar projections to every lobule of the cerebellum. Notably, projections originating from asso

SUBMITTER: Henschke JU 

PROVIDER: S-EPMC7428308 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature