Risk Factors for Kaposi's Sarcoma-Associated Herpesvirus DNA in Blood and in Saliva in Rural Uganda.

ABSTRACT:

Background

Detectable Kaposi's sarcoma-associated herpesvirus (KSHV) DNA in blood and increased antibody titres may indicate KSHV reactivation, while the transmission of KSHV occurs via viral shedding in saliva.

Methods

We investigated the risk factors for KSHV DNA detection by real-time polymerase chain reaction in blood and by viral shedding in saliva, in 878 people aged 3 to 89 years of both sexes in a rural Ugandan population cohort. Helminths were detected using microscopy and the presence of malaria parasitaemia was identified using rapid diagnostic tests. Regression modelling was used for a statistical analysis.

Results

The KSHV viral load in blood did not correlate with the viral load in saliva, suggesting separate immunological controls within each compartmen

SUBMITTER: Nalwoga A 

PROVIDER: S-EPMC7428384 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature