Identifying interactive biological pathways associated with reading disability.

ABSTRACT:

Introduction

Past research has suggested that reading disability is a complex disorder involving genetic and environment contributions, as well as gene-gene and gene-environment interaction, but to date little is known about the underlying mechanisms.

Method

Using the Avon Longitudinal Study of Parents and Children, we assessed the contributions of genetic, demographic, and environmental variables on case-control status using machine learning. We investigated the functional interactions between genes using pathway and network analysis.

Results

Our results support a systems approach to studying the etiology of reading disability with many genes (e.g., RAPGEF2, KIAA0319, DLC1) and biological pathways (e.g., neuron migration, positive regulation of dendrite regulation, n

SUBMITTER: Lancaster HS 

PROVIDER: S-EPMC7428467 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature