Altered gut bacterial-fungal interkingdom networks in patients with current depressive episode.

ABSTRACT:

Introduction

Bacterial dysbiosis has been described in patients with current depressive episode (CDE); however, the fungal composition in the gut has not been investigated in these patients.

Methods

Here, we characterized the fungal gut mycobiota in patients with CDE. We systematically characterized the microbiota and mycobiota in fecal samples obtained from 24 patients with CDE and 16 healthy controls (HC) using 16S rRNA gene- and ITS1-based DNA sequencing, respectively.

Results

In patients with CDE, bacterial dysbiosis was characterized by an altered composition and reduced correlation network density, and the gut mycobiota was characterized by a relative reduction in alpha diversity and altered composition. Most notably, the CDE group had higher levels of Candida a

SUBMITTER: Jiang HY 

PROVIDER: S-EPMC7428472 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature