Multi-voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity.

ABSTRACT:

Introduction

Resting state functional magnetic resonance imaging (rsfMRI) studies demonstrate that individuals with posttraumatic stress disorder (PTSD) exhibit atypical functional connectivity (FC) between the amygdala, involved in the generation of emotion, and regions responsible for emotional appraisal (e.g., insula, orbitofrontal cortex [OFC]) and regulation (prefrontal cortex [PFC], anterior cingulate cortex). Consequently, atypical amygdala FC within an emotional processing and regulation network may be a defining feature of PTSD, although altered FC does not seem constrained to one brain region. Instead, altered amygdala FC involves a large, distributed brain network in those with PTSD. The present study used a machine-learning data-driven approach, multi-voxel pattern anal

SUBMITTER: Fitzgerald JM 

PROVIDER: S-EPMC7428479 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature