The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats.

ABSTRACT:

Background and purpose

We focused on the, yet undescribed, therapy effect of the stable gastric pentadecapeptide BPC 157 in hippocampal ischemia/reperfusion injuries, after bilateral clamping of the common carotid arteries in rats. The background is the proven therapy effect of BPC 157 in ischemia/reperfusion injuries in different tissues. Furthermore, there is the subsequent oxidative stress counteraction, particularly when given during reperfusion. The recovering effect it has on occluded vessels, results with activation of the alternative pathways, bypassing the occlusion in deep vein thrombosis. Finally, the BPC 157 therapy benefits with its proposed role as a novel mediator of Roberts' cytoprotection and bidirectional effects in the gut-brain axis.

Materials and methods

SUBMITTER: Vukojevic J 

PROVIDER: S-EPMC7428500 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature