Neural substrates underlying progressive micrographia in Parkinson's disease.

ABSTRACT:

Introduction

The neural substrates associated with the development of micrographia remain unknown. We aimed to elucidate the neural substrates underlying micrographia in Parkinson's disease (PD) patients.

Methods

Forty PD patients and 20 healthy controls underwent handwriting tests that involved free writing and copying. We measured the size of each letter and the resting cerebral glucose metabolic rate of the PD patients and another group of age- and sex-matched 14 healthy controls (HCs), who had not participated in the writing tests, using resting-state 18F-fluorodeoxyglucose positron emission tomography.

Results

In the PD patients, the prevalence of consistent micrographia (CM) associated with free writing was 2.5% for both tasks. Alternatively, the prevalence of p

SUBMITTER: Kanno S 

PROVIDER: S-EPMC7428504 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature