Identifying Temporal Relationships Between In-Hospital Adverse Events After Implantation of Durable Left Ventricular Assist Devices.

ABSTRACT: Background This study evaluated the impact of adverse events (AEs) on the development of subsequent AEs after left ventricular assist device (LVAD) surgery. Methods and Results The INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) was used to identify primary durable LVADs implanted between 2006 and 2016. The temporal relationships between AEs occurring during the index hospitalization were evaluated using separate risk-adjusted Cox proportional hazard models. LVADs were implanted in 18 763 patients. The strongest positive relationships were renal failure leading to hepatic dysfunction (hazard ratio [HR], 6.62; 95% CI, 5.12-8.54; P<0.001), respiratory failure leading to renal failure (HR, 5.51; 95% CI, 4.79-6.34; P<0.001), respiratory failure lead

SUBMITTER: Kilic A 

PROVIDER: S-EPMC7428534 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature