CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1.

ABSTRACT: Background Although multiple signaling cascades and molecules contributing to the pathophysiological process have been studied, the treatments for stroke against present targets have not acquired significant clinical progress. Although CARD3 (caspase activation and recruitment domain 3) protein is an important factor involved in regulating immunity, inflammation, lipid metabolism, and apoptosis, its role in cerebral stroke is currently unknown. Methods and Results Using a mouse model of ischemia-reperfusion (I-R) injury based on transient blockage of the middle cerebral artery, we have found that CARD3 expression is upregulated in a time-dependent manner during I-R injury. Further animal study revealed that, relative to control mice, CARD3-knockout mice exhibited decreased inflammatory res

SUBMITTER: Wu X 

PROVIDER: S-EPMC7428569 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature