Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study.

ABSTRACT: Background Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom. Methods and Results Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used τ², I², and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hos

SUBMITTER: Heikkila K 

PROVIDER: S-EPMC7428570 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature