Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes.

ABSTRACT: Background Mitochondrial transplantation has been recently explored for treatment of very ill cardiac patients. However, little is known about the intracellular consequences of mitochondrial transplantation. This study aims to assess the bioenergetics consequences of mitochondrial transplantation into normal cardiomyocytes in the short and long term. Methods and Results We first established the feasibility of autologous, non-autologous, and interspecies mitochondrial transplantation. Then we quantitated the bioenergetics consequences of non-autologous mitochondrial transplantation into cardiomyocytes up to 28 days using a Seahorse Extracellular Flux Analyzer. Compared with the control, we observed a statistically significant improvement in basal respiration and ATP production 2-day post-tr

SUBMITTER: Ali Pour P 

PROVIDER: S-EPMC7428632 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature