Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking.

ABSTRACT: The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic drugs) when interacting with the main protease (M^pro) of SARS-CoV-2. Additionally, we tested the binding affinity of photoproducts identified after irradiation of phenothiazines with Nd:YAG laser beam at 266 nm respectively 355 nm. Our results reveal that thioridazine and its identified photoproducts (mesoridazine and sulforidazine) have high biological activity on the virus M^pro. This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this ou

SUBMITTER: Udrea AM 

PROVIDER: S-EPMC7428740 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature