Age-dependent expression of cancer-related genes in a long-lived seabird.

ABSTRACT: Studies of model animals like mice and rats have led to great advances in our understanding of the process of tumorigenesis, but this line of study has less to offer for understanding the mechanisms of cancer resistance. Increasing the diversity of nonmodel species from the perspective of molecular mechanisms of natural cancer resistance can lead to new insights into the evolution of protective mechanisms against neoplastic processes and to a wider understanding of natural cancer defense mechanisms. Such knowledge could then eventually be harnessed for the development of human cancer therapies. We suggest here that seabirds are promising, albeit currently completely ignored candidates for studying cancer defense mechanisms, as they have a longer maximum life span than expected from their b

SUBMITTER: Meitern R 

PROVIDER: S-EPMC7428815 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature