Serum active 1,25(OH)₂D, but not inactive 25(OH)D vitamin D levels are associated with cardiometabolic and cardiovascular disease risk in psoriasis.

ABSTRACT:

Background and aims

Vitamin D exists as an inactive 25-hydroxyvitamin D (25(OH)D) in the bloodstream, which is converted to active 1,25-dihydroxyvitaminD (1,25(OH)₂D) in target tissues. Cohort studies reporting cardiovascular disease among individuals with low vitamin D are inconsistent and solely measure 25(OH)D. Psoriasis, a chronic inflammatory disease, is a vitamin D deficient state and is associated with increased cardiovascular disease risk. While serum 25(OH)D is routinely measured, we hypothesized that measurement of 1,25(OH)₂D in psoriasis may perform better than 25(OH)D in capturing cardiovascular risk.

Methods

Consecutive psoriasis patients (N = 122) at baseline underwent FDG PET/CT and CCTA scans to measure visceral adipose volume, aortic va

SUBMITTER: Playford MP 

PROVIDER: S-EPMC7428835 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature