Ontology highlight
ABSTRACT:
SUBMITTER: Nanbakhsh A
PROVIDER: S-EPMC7428857 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cancer immunology research 20190912 10
Natural killer (NK) cells generate proinflammatory cytokines that are required to contain infections and tumor growth. However, the posttranscriptional mechanisms that regulate NK cell functions are not fully understood. Here, we define the role of the microRNA cluster known as <i>Mirc11</i> (which includes <i>miRNA-23a, miRNA-24a</i>, and <i>miRNA-27a</i>) in NK cell-mediated proinflammatory responses. Absence of <i>Mirc11</i> did not alter the development or the antitumor cytotoxicity of NK ce ...[more]