In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography.

ABSTRACT:

Introduction

Hypoxia-induced α _ν β ₃ integrin and aminopeptidase N (APN/CD13) receptor expression play an important role in tumor neoangiogenesis. APN/CD13-specific ⁶⁸Ga-NOTA-c(NGR), α _ν β ₃ integrin-specific ⁶⁸Ga-NODAGA-[c(RGD)]₂, and hypoxia-specific ⁶⁸Ga-DOTA-nitroimidazole enable the in vivo detection of the neoangiogenic process and the hypoxic regions in the tumor mass using positron emission tomography (PET) imaging. The aim of this study was to evaluate whether ⁶⁸Ga-NOTA-c(NGR) and ⁶⁸Ga-DOTA-nitroimidazole allow the in vivo noninvasive detection of the temporal changes of APN/CD13 expression and hypoxia in expe

SUBMITTER: Kis A 

PROVIDER: S-EPMC7428931 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature