Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models.

ABSTRACT: Metronomic chemotherapy refers to the minimum biologically effective doses of a chemotherapy agent given as a continuous regimen without extended rest periods. Drug repurposing is defined as the use of an already known drug for a new medical indication, different from the original one. In oncology the combination of these two therapeutic approaches is called "Metronomics". The aim of this work is to evaluate the therapeutic effect of cyclophosphamide in a metronomic schedule in combination with the repurposed drug losartan in two genetically different mice models of triple negative breast cancer. Our findings showed that adding losartan to metronomic cyclophosphamide significantly improved the therapeutic outcome. In both models the combined treatment increased the mice's survival without

SUBMITTER: Mainetti LE 

PROVIDER: S-EPMC7429183 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature