Positron Emission Tomography Imaging of Staphylococcus aureus Infection Using a Nitro-Prodrug Analogue of 2-[¹⁸F]F-p-Aminobenzoic Acid.

ABSTRACT: Deep-seated bacterial infections caused by pathogens such as Staphylococcus aureus are difficult to diagnose and treat and are thus a major threat to human health. In previous work we demonstrated that positron emission tomography (PET) imaging with 2-[¹⁸F]F-p-aminobenzoic acid (2-[¹⁸F]F-PABA) could noninvasively identify, localize, and monitor S. aureus infection with excellent sensitivity and specificity in a rodent soft tissue infection model. However, 2-[¹⁸F]F-PABA is rapidly N-acetylated and eliminated, and in an attempt to improve radiotracer accumulation in bacteria we adopted a prodrug strategy in which the acid was protected by an ester and the amine was replaced with a nitro group. Metabolite analysis indicated that the nitro

SUBMITTER: Li Y 

PROVIDER: S-EPMC7429255 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature