Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

ABSTRACT: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r_g ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis

SUBMITTER: Munn-Chernoff MA 

PROVIDER: S-EPMC7429266 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature