Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.

ABSTRACT:

Background

Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. This study tested the hypothesis that differences in brain Tau amounts and in the activity of mitochondria-adenosine triphosphate (ATP)-Nuak1-Tau cascade between the neonatal and adult mice contribute to the age-dependent effects of sevoflurane on cognitive function.

Methods

6- and 60-day-old mice of both sexes received anesthesia with 3% sevoflurane for 2 h daily for 3 days. Biochemical methods were used to measure amounts of Tau, phosphorylated Tau, Nuak1, ATP concentrations, and mitochondrial metabolism in the cerebral cortex and hippocampus. The Morris water maze test was used to evaluate cognitive function in the neonatal and adult mice.

Results</

SUBMITTER: Yu Y 

PROVIDER: S-EPMC7429299 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature