The association of white matter free water with cognition in older adults.

ABSTRACT:

Background

Extracellular free water within cerebral white matter tissue has been shown to increase with age and pathology, yet the cognitive consequences of free water in typical aging prior to the development of neurodegenerative disease remains unclear. Understanding the contribution of free water to cognitive function in older adults may provide important insight into the neural mechanisms of the cognitive aging process.

Methods

A diffusion-weighted MRI measure of extracellular free water as well as a commonly used diffusion MRI metric (fractional anisotropy) along nine bilateral white matter pathways were examined for their relationship with cognitive function assessed by the NIH Toolbox Cognitive Battery in 47 older adults (mean age ​= ​74.4 years, SD ​= ​5.4 years, ran

SUBMITTER: Gullett JM 

PROVIDER: S-EPMC7429363 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature