Structures of metabotropic GABA_B receptor.

ABSTRACT: Stimulation of the metabotropic GABA_B receptor by γ-aminobutyric acid (GABA) results in prolonged inhibition of neurotransmission, which is central to brain physiology¹. GABA_B belongs to family C of the G-protein-coupled receptors, which operate as dimers to transform synaptic neurotransmitter signals into a cellular response through the binding and activation of heterotrimeric G proteins^2,3. However, GABA_B is unique in its function as an obligate heterodimer in which agonist binding and G-protein activation take place on distinct subunits^4,5. Here we present cryo-electron microscopy structures of heterodimeric and homodimeric full-length GABA_B receptors. Complemented by cellular signalling assays and atomistic si

SUBMITTER: Papasergi-Scott MM 

PROVIDER: S-EPMC7429364 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature