Structure of cytotoxic associated antigen A protein of Helicobacter pylori from Bali and Lombok isolates of Indonesia.

ABSTRACT:

Background and aim

Helicobacter pylori is a well-known zoonotic agent with worldwide distribution. In Indonesia, only one report regarding the variation within the cytotoxic associated antigen A (CagA) protein of H. pylori has been described in the literature, which was conducted in Manado, South Sulawesi. There remains no report concerning the structure of this protein, particularly for the Bali and Lombok isolates. The objective of this study was to investigate the diversity of H. pylori CagA amino acid sequences of Bali and Lombok isolates, to predict their molecular structures and conduct toxicity examination of CagA on gastric cells.

Materials and methods

A total of 36 samples were used in equal proportions for each pathologic condition. DNA

SUBMITTER: Suharsono H 

PROVIDER: S-EPMC7429398 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature