Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population.

ABSTRACT:

Background

Osteonecrosis of the femoral head (ONFH) is a complicated disease associated with trauma, hormone abuse and excessive alcohol consumption. Polymorphisms of long non-coding RNAs have been also linked with the development of ONFH. Our research aimed to explore the relationship between CARMEN (Cardiac Mesoderm Enhancer-Associated Non-Coding RNA) variants and ONFH risk.

Methods

Our study used Agena MassARRAY Assay to genotype 6 selected single nucleotide polymorphisms (SNPs) in 731 participants (308 alcohol-induced ONFH patients and 423 controls). We used odds ratios (ORs) and 95% confidence intervals (CIs) to calculate the effect of gene polymorphisms on the occurrence of alcohol-induced ONFH by logistic regression analysis and haplotype analysis.

Results

Our

SUBMITTER: Guo Y 

PROVIDER: S-EPMC7429464 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature